Ocular complications in HIV positive patients on antiretroviral therapy in Ghana
Identifieur interne : 000170 ( Main/Exploration ); précédent : 000169; suivant : 000171Ocular complications in HIV positive patients on antiretroviral therapy in Ghana
Auteurs : Alexander Martin-Odoom [Ghana] ; Evelyn Yayra Bonney [Ghana] ; Derek Kofi Opoku [Ghana]Source :
- BMC Ophthalmology [ 1471-2415 ] ; 2016.
Descripteurs français
- KwdFr :
- Acuité visuelle, Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Ghana (épidémiologie), Humains, Infections à VIH (), Infections à VIH (traitement médicamenteux), Jeune adulte, Maladies de l'oeil (épidémiologie), Maladies de l'oeil (étiologie), Mâle, Numération des lymphocytes CD4, Prévalence, Thérapie antirétrovirale hautement active, Études transversales.
- MESH :
- traitement médicamenteux : Infections à VIH.
- épidémiologie : Ghana, Maladies de l'oeil.
- étiologie : Maladies de l'oeil.
- Acuité visuelle, Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Infections à VIH, Jeune adulte, Mâle, Numération des lymphocytes CD4, Prévalence, Thérapie antirétrovirale hautement active, Études transversales.
English descriptors
- KwdEn :
- Adult, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Cross-Sectional Studies, Eye Diseases (epidemiology), Eye Diseases (etiology), Female, Ghana (epidemiology), HIV Infections (complications), HIV Infections (drug therapy), Humans, Male, Middle Aged, Prevalence, Risk Factors, Visual Acuity, Young Adult.
- MESH :
- complications : HIV Infections.
- drug therapy : HIV Infections.
- epidemiology : Eye Diseases, Ghana.
- etiology : Eye Diseases.
- Adult, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Prevalence, Risk Factors, Visual Acuity, Young Adult.
Abstract
Patients infected with human immunodeficiency virus (HIV) usually develop some form of ocular complication in the different segments of the eye due to immune deficiency. In Ghana, data regarding ocular complications among HIV/AIDS patients is scarce. This study investigated the occurrence of ocular complications in HIV infected patients undergoing antiretroviral therapy at the Agogo Presbyterian Hospital in the Ashanti Region of Ghana.
Blood samples were taken from 100 confirmed HIV infected patients. The CD4 + T cell count and WHO clinical staging were determined. The patients were taken through thorough ophthalmic assessments to determine any ocular complications.
Forty-eight patients (48 %) had at least one HIV-related ocular complication. These complications occurred more frequently among those with CD4 counts below 200 cells/μL. Of the participants with HIV-related ocular complications, 11 (23 %) had retinal microvasculopathy, 10 (21 %) showed allergic conjunctivitis, 7 (15 %) had HIV retinopathy and 7 (15 %) had conjunctival carcinoma. All the participants in the study were on first-line antiretroviral therapy; 68 % were females and 72 % were in the Stage 3 of the WHO Clinical Staging of HIV infection.
The prevalence of ocular complications in HIV positive persons under treatment in Ghana is high. Lower CD4 + T cell counts coupled with age were predisposing factors to HIV-related ocular complications.
Url:
DOI: 10.1186/s12886-016-0310-5
PubMed: 27487853
PubMed Central: 4973055
Affiliations:
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Le document en format XML
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Ghana</orgName></affiliation></author><author><name sortKey="Bonney, Evelyn Yayra" sort="Bonney, Evelyn Yayra" uniqKey="Bonney E" first="Evelyn Yayra" last="Bonney">Evelyn Yayra Bonney</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Opoku, Derek Kofi" sort="Opoku, Derek Kofi" uniqKey="Opoku D" first="Derek Kofi" last="Opoku">Derek Kofi Opoku</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Department of Medical Laboratory Sciences, School of Biomedical & Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Medical Laboratory Sciences, School of Biomedical & Allied Health Sciences, College of Health Sciences, University of Ghana, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author></analytic><series><title level="j">BMC Ophthalmology</title><idno type="eISSN">1471-2415</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antiretroviral Therapy, Highly Active</term><term>CD4 Lymphocyte Count</term><term>Cross-Sectional Studies</term><term>Eye Diseases (epidemiology)</term><term>Eye Diseases (etiology)</term><term>Female</term><term>Ghana (epidemiology)</term><term>HIV Infections (complications)</term><term>HIV Infections (drug therapy)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Risk Factors</term><term>Visual Acuity</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acuité visuelle</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Ghana (épidémiologie)</term><term>Humains</term><term>Infections à VIH ()</term><term>Infections à VIH (traitement médicamenteux)</term><term>Jeune adulte</term><term>Maladies de l'oeil (épidémiologie)</term><term>Maladies de l'oeil (étiologie)</term><term>Mâle</term><term>Numération des lymphocytes CD4</term><term>Prévalence</term><term>Thérapie antirétrovirale hautement active</term><term>Études transversales</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Eye Diseases</term><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Eye Diseases</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Ghana</term><term>Maladies de l'oeil</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Maladies de l'oeil</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Antiretroviral Therapy, Highly Active</term><term>CD4 Lymphocyte Count</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Risk Factors</term><term>Visual Acuity</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acuité visuelle</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Infections à VIH</term><term>Jeune adulte</term><term>Mâle</term><term>Numération des lymphocytes CD4</term><term>Prévalence</term><term>Thérapie antirétrovirale hautement active</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Patients infected with human immunodeficiency virus (HIV) usually develop some form of ocular complication in the different segments of the eye due to immune deficiency. In Ghana, data regarding ocular complications among HIV/AIDS patients is scarce. This study investigated the occurrence of ocular complications in HIV infected patients undergoing antiretroviral therapy at the Agogo Presbyterian Hospital in the Ashanti Region of Ghana.</p></sec><sec><title>Methods</title><p>Blood samples were taken from 100 confirmed HIV infected patients. The CD4 + T cell count and WHO clinical staging were determined. The patients were taken through thorough ophthalmic assessments to determine any ocular complications.</p></sec><sec><title>Results</title><p>Forty-eight patients (48 %) had at least one HIV-related ocular complication. These complications occurred more frequently among those with CD4 counts below 200 cells/μL. Of the participants with HIV-related ocular complications, 11 (23 %) had retinal microvasculopathy, 10 (21 %) showed allergic conjunctivitis, 7 (15 %) had HIV retinopathy and 7 (15 %) had conjunctival carcinoma. All the participants in the study were on first-line antiretroviral therapy; 68 % were females and 72 % were in the Stage 3 of the WHO Clinical Staging of HIV infection.</p></sec><sec><title>Conclusion</title><p>The prevalence of ocular complications in HIV positive persons under treatment in Ghana is high. Lower CD4 + T cell counts coupled with age were predisposing factors to HIV-related ocular complications.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Douek, Dc" uniqKey="Douek D">DC Douek</name></author><author><name sortKey="Roederer, M" uniqKey="Roederer M">M Roederer</name></author><author><name sortKey="Koup, Ra" uniqKey="Koup R">RA Koup</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kumarasamy, N" uniqKey="Kumarasamy N">N Kumarasamy</name></author><author><name sortKey="Solomon, S" uniqKey="Solomon S">S Solomon</name></author><author><name sortKey="Chaguturu, Sk" uniqKey="Chaguturu S">SK Chaguturu</name></author><author><name sortKey="Cecelia, Aj" uniqKey="Cecelia A">AJ Cecelia</name></author><author><name sortKey="Vallabhaneni, S" uniqKey="Vallabhaneni S">S Vallabhaneni</name></author><author><name sortKey="Flanigan, Tp" uniqKey="Flanigan T">TP Flanigan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holbrook, J" uniqKey="Holbrook J">J Holbrook</name></author><author><name sortKey="Jabs, Da" uniqKey="Jabs D">DA Jabs</name></author><author><name sortKey="Weinberg, Dv" uniqKey="Weinberg D">DV Weinberg</name></author><author><name sortKey="Lewis, Ra" uniqKey="Lewis R">RA Lewis</name></author><author><name sortKey="David, Md" uniqKey="David M">MD David</name></author><author><name sortKey="Friedberg, D" uniqKey="Friedberg D">D Friedberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kestelyn, Pg" uniqKey="Kestelyn P">PG Kestelyn</name></author><author><name sortKey="Cunningham, Et" uniqKey="Cunningham E">ET Cunningham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assefa, Y" uniqKey="Assefa Y">Y Assefa</name></author><author><name sortKey="Yohannes, A" uniqKey="Yohannes A">A Yohannes</name></author><author><name sortKey="Melese, A" uniqKey="Melese A">A Melese</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Vrabec, Tr" uniqKey="Vrabec T">TR Vrabec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jabs, Da" uniqKey="Jabs D">DA Jabs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Awan, Hr" uniqKey="Awan H">HR Awan</name></author><author><name sortKey="Adala, Hs" uniqKey="Adala H">HS Adala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biswas, J" uniqKey="Biswas J">J Biswas</name></author><author><name sortKey="Madhwan, Hn" uniqKey="Madhwan H">HN Madhwan</name></author><author><name sortKey="George, Ae" uniqKey="George A">AE George</name></author><author><name sortKey="Kumarasamy, N" uniqKey="Kumarasamy N">N Kumarasamy</name></author><author><name sortKey="Solomon, S" uniqKey="Solomon S">S Solomon</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lewallen, S" uniqKey="Lewallen S">S Lewallen</name></author><author><name sortKey="Kumwenda, J" uniqKey="Kumwenda J">J Kumwenda</name></author><author><name sortKey="Maher, D" uniqKey="Maher D">D Maher</name></author><author><name sortKey="Harries, Ad" uniqKey="Harries A">AD Harries</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kestelyn, Pg" uniqKey="Kestelyn P">PG Kestelyn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rauz, S" uniqKey="Rauz S">S Rauz</name></author><author><name sortKey="Murray, Pi" uniqKey="Murray P">PI Murray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ives, Dv" uniqKey="Ives D">DV Ives</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Van, Da" uniqKey="Van D">DA Van</name></author><author><name sortKey="Gawie, Dt" uniqKey="Gawie D">DT Gawie</name></author><author><name sortKey="Emma, B" uniqKey="Emma B">B Emma</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Ghana</li></country><region><li>Région du Grand Accra</li></region><settlement><li>Accra</li></settlement><orgName><li>Université du Ghana</li></orgName></list><tree><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Martin Odoom, Alexander" sort="Martin Odoom, Alexander" uniqKey="Martin Odoom A" first="Alexander" last="Martin-Odoom">Alexander Martin-Odoom</name></region><name sortKey="Bonney, Evelyn Yayra" sort="Bonney, Evelyn Yayra" uniqKey="Bonney E" first="Evelyn Yayra" last="Bonney">Evelyn Yayra Bonney</name><name sortKey="Opoku, Derek Kofi" sort="Opoku, Derek Kofi" uniqKey="Opoku D" first="Derek Kofi" last="Opoku">Derek Kofi Opoku</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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